Title :
Initiation and termination of spiral waves in a two-dimensional bidomain model of cardiac tissue
Author :
Thakor, NV ; Fishler, MG
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA
Abstract :
Spiral waves in cardiac tissue serve as a simplified model of ventricular fibrillation (VF). Initiation and termination of the spiral wave is studied in a computer model. The computer model comprises a two dimensional, bidomain, discontinuous and anisotropic network of cardiac cells. In an analogous experimental preparation, electrical activity is imaged using a voltage sensitive fluorescent dye. The model and the experiment reproduce similar spiral wave activity. Application of electrical shock of adequate strength, in the model as well as the experiment, eliminated the spiral wave pattern.
Keywords :
bioelectric phenomena; biology computing; cardiology; cellular biophysics; digital simulation; physiological models; anisotropic network; cardiac cells; computer model; electrical activity; experimental preparation; spiral wave pattern; spiral waves initiation; spiral waves termination; ventricular fibrillation; voltage sensitive fluorescent dye; Anisotropic magnetoresistance; Biomembranes; Cardiac tissue; Conductivity; Electric shock; Extracellular; Fibrillation; Fluorescence; Spirals; Voltage;
Conference_Titel :
Computers in Cardiology, 1996
Conference_Location :
Indianapolis, IN, USA
Print_ISBN :
0-7803-3710-7
DOI :
10.1109/CIC.1996.542515
