Initiation and termination of spiral waves in a two-dimensional bidomain model of cardiac tissue

Author

Thakor, NV ; Fishler, MG

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA

fYear

1996

Firstpage

229

Lastpage

232

Abstract

Spiral waves in cardiac tissue serve as a simplified model of ventricular fibrillation (VF). Initiation and termination of the spiral wave is studied in a computer model. The computer model comprises a two dimensional, bidomain, discontinuous and anisotropic network of cardiac cells. In an analogous experimental preparation, electrical activity is imaged using a voltage sensitive fluorescent dye. The model and the experiment reproduce similar spiral wave activity. Application of electrical shock of adequate strength, in the model as well as the experiment, eliminated the spiral wave pattern.

Keywords

bioelectric phenomena; biology computing; cardiology; cellular biophysics; digital simulation; physiological models; anisotropic network; cardiac cells; computer model; electrical activity; experimental preparation; spiral wave pattern; spiral waves initiation; spiral waves termination; ventricular fibrillation; voltage sensitive fluorescent dye; Anisotropic magnetoresistance; Biomembranes; Cardiac tissue; Conductivity; Electric shock; Extracellular; Fibrillation; Fluorescence; Spirals; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology, 1996

Conference_Location

Indianapolis, IN, USA

ISSN

0276-6547

Print_ISBN

0-7803-3710-7

Type

conf

DOI

10.1109/CIC.1996.542515

Filename

542515