Title :
Chaperoned function of HSP72 in hepatocellular carcinomas
Author :
Xiaoping Wang ; HuanPing Lin ; Bing Xu ; JingGang Fang ; KePei Zhang ; Yixin Yang
Author_Institution :
Key Lab. of Mol. Biol. & Pathology, Shaanxi Univ. of Chinese Med., Xianyang, China
Abstract :
Heat shock protein 72 (HSP72) is highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 in the development and progression of gastrointestinal carcinomas but detailed mechanisms are still ambiguous. Human hepatocellular carcinomas are common gastrointestinal malignant carcinomas in the world. The studies indicated that HSP72 chaperoned alpha-fetoprotein (AFP) and HBx in hepatocellular carcinoma. The further researches demonstrated that HSP72-AFP recombined vaccine could elicit specific anti-tumor immunity. The high-level expression of HSP72 may be not only used as diagnostic or prognostic markers for hepatocellular carcinomas but also as better immunotherapeutic vaccines in the cancers.
Keywords :
cancer; cellular biophysics; drug delivery systems; drugs; molecular biophysics; patient diagnosis; proteins; tumours; HSP72 chaperoned alpha-fetoprotein; HSP72-AFP recombined vaccine; cancer tissues; chaperoned function; diagnostic markers; gastrointestinal carcinomas development; gastrointestinal carcinomas progression; gastrointestinal malignant carcinomas; heat shock protein 72; high-level HSP72 expression; human hepatocellular carcinomas; immunotherapeutic vaccines; prognostic markers; specific antitumor immunity; Biomembranes; Cancer; Correlation; Genetics; Heating; Immune system; Proteins; Heat shock protein 72(HSP72); hepatocellular carcinomas; molecular chaperone;
Conference_Titel :
Electronics, Computer and Applications, 2014 IEEE Workshop on
Conference_Location :
Ottawa, ON
DOI :
10.1109/IWECA.2014.6845799
