Title :
Physiologic basis of spin lattice relaxation time in normal rat tissues
Author :
Akber, Syed Farooq
Author_Institution :
Dept. of Chem., Simon Fraser Univ., Burnaby, BC, Canada
Abstract :
The physical and biological mechanism of oxygen availability and oxygen consumption and its influence on proton spin-lattice relaxation time (T1) in normal rat tissues is discussed. A systematic approach is used to find a correlation between T1 and oxygen consumption rate. These data were abstracted from the literature and evaluated using a weighted-least-squares linear regression analysis. It is observed that T1 values of normal rat tissues from different organs reveal a linear function of the oxygen consumption rate, with a correlation coefficient of 0.66. The relationship between water and T1 yields no correlation. It is concluded that the variation of T1 among different types of tissue depend on the rate at which paramagnetic molecular oxygen dissolved in the cell-associated water is consumed
Keywords :
biomagnetism; nuclear spin-lattice relaxation; physiology; proton magnetic resonance; O2; T1; cell-associated water; normal rat tissues; proton spin-lattice relaxation time; spin lattice relaxation time; weighted-least-squares linear regression analysis; Biological system modeling; Biological systems; Biological tissues; Cells (biology); Lattices; Least squares methods; Oxygen; Paramagnetic materials; Protons; Rats;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.95884
