Title :
A preliminary work on evolutionary identification of protein variants and new proteins on grids
Author :
Boisson, Jean-Charles ; Jourdan, Laetitia ; Talbi, El-Ghazali ; Rolando, Christian
Author_Institution :
LIFL/INRIA Futurs, Lille I Univ., Villeneuve d´´Ascq, France
Abstract :
Protein identification is one of the major task of Proteomics researchers. Protein identification could be resumed by searching the best match between an experimental mass spectrum and proteins from a database. Nevertheless this approach can not be used to identify new proteins or protein variants. In this paper an evolutionary approach is proposed to discover new proteins or protein variants thanks a "de novo sequencing" method. This approach has been experimented on a specific grid called Grid5000 with simulated spectra and also real spectra.
Keywords :
biological techniques; biology computing; evolutionary computation; grid computing; identification; proteins; Grid5000; de novo sequencing method; evolutionary identification; experimental mass spectrum; protein variant; Amino acids; Biological system modeling; Cells (biology); Chemicals; Databases; Mass spectroscopy; Peptides; Proteins; Proteomics; Sequences;
Conference_Titel :
Advanced Information Networking and Applications, 2006. AINA 2006. 20th International Conference on
Print_ISBN :
0-7695-2466-4
DOI :
10.1109/AINA.2006.48
