Ectopic activity generated by early after-depolarizations in ventricular tissue: a computer simulation study

Author

Saiz, Jiavier ; Monserrat, Marta ; Ferrero, J.M. ; Ferrero, Jose M., Jr. ; Thako, N.V.

Author_Institution

L.I.B.-D.I.E., Univ. Politecnica de Valencia, Spain

fYear

1996

Firstpage

601

Lastpage

604

Abstract

A computer model of two partially coupled ventricular fibers was used to study conditions in which EADs generated in a zone of ventricular myocardium may propagate to other zones, inducing ectopic activity. The model consists of two one-dimensional arrays of cells coupled by a resistance R. EADs are induced in one of the segments while the other is kept under normal conditions. For values of R in the range from 38 Ω cm² to 50 Ω cm², the second EAD that appears in the EAD segment propagates to the normal segment as an ectopic beat. For R values out of this range the EAD only increases the action potential duration in some cells of the normal zone and ectopic activity in the normal cells is not observed

Keywords

bioelectric phenomena; biology computing; cellular biophysics; digital simulation; physiological models; R values; action potential duration; cardiac electrophysiology; computer simulation study; early after-depolarizations; ectopic activity; ectopic beat; normal cells; one-dimensional cellular arrays; partially coupled ventricular fibers; ventricular tissue; Biomedical computing; Biomedical engineering; Biomembranes; Calcium; Computational modeling; Computer simulation; Electric resistance; Heart rate variability; Immune system; Myocardium;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology, 1996

Conference_Location

Indianapolis, IN

ISSN

0276-6547

Print_ISBN

0-7803-3710-7

Type

conf

DOI

10.1109/CIC.1996.542608

Filename

542608