The effects of magnetic fields on the differentiation and intracellular free calcium of bone marrow mesenchymal stem cells

Author

Zhao, Wenchun ; Ma, Weiming ; Wu, Hua

Author_Institution

Inst. of Electr. & Inf. Eng., Navel Univ. of Eng., Wuhan

fYear

2008

Firstpage

1

Lastpage

3

Abstract

To study the effects of magnetic fields (MFs) of 50 Hz and 1.1 mT on the differentiation and intracellular free calcium of bone marrow mesenchymal stem cells (MSCs). MSCs were isolated and cultured in vitro. The fourth-passage cells were harvested and exposed in 50 Hz sinusoidal magnetic fields (MFs) under different conditions. The cellular differentiation and the intercellular Ca²⁺ level were investigated at different time. MFs (50 Hz, 1.1 mT) enhanced the cellular differentiation (P < 0.05), and the intracellular free Ca²⁺ concentration in MSCs could be significantly raised too. Conclusion: MFs (50 Hz, 1.1 mT) changes intracellular free calcium ion concentration of MSCs, which plays a key role in the differentiation of MSCs.

Keywords

biological effects of fields; bone; cellular effects of radiation; magnetic field effects; bone marrow mesenchymal stem cells; cellular differentiation; frequency 50 Hz; intracellular free calcium; sinusoidal magnetic field effects; Animals; Biomedical engineering; Bones; Calcium; Cows; Educational institutions; Mice; Power engineering and energy; Stem cells; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Automation Congress, 2008. WAC 2008. World

Conference_Location

Hawaii, HI

Print_ISBN

978-1-889335-38-4

Electronic_ISBN

978-1-889335-37-7

Type

conf

Filename

4699293