Elastic image registration of diagnostic brain MR and limited view intra operative MR using mutual information

Neurosurgery requires accurate surgical planning and guidance because of complex and delicate structures in the brain. Over the course of a neurosurgical procedure, the brain changes its shape in reaction to mechanical and physiological changes associated with the surgery (loss of cerebro-spinal fluid and gravity force). Hence the use of elastic registration is required. We propose a method for registration of full view pre-operative and limited view intra-operative brain images. A polynomial formulation is used for curved transformation.