Title :
Flow attachment assessment of a peptide-conjugated polymeric contrast agent for targeted ultrasound imaging
Author :
Lathia, Justin D. ; Oeffinger, Brian E. ; Barbee, Kenneth A. ; Wheatley, Margaret A.
Author_Institution :
Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA
Abstract :
Fibronectin peptide fragments were conjugated to PIA ultrasound contrast agents to develop a targeted contrast agent that enhances ultrasound imaging. The microspheres were coated with generic GRGDS and REDV peptide sequences that target integrins expressed in angiogenesis, αvβ3 and αvβ5. The microspheres bound to human breast cancer cells in vitro within 3 minutes under flow conditions. The GRGDS and REDV peptide modified microspheres show promise as candidates for targeted therapeutic imaging and eventually drug delivery vehicles.
Keywords :
biomedical materials; biomedical ultrasonics; cancer; drug delivery systems; organic compounds; αvβ3; αvβ5; 3 min; REDV peptide sequences; drug delivery vehicles; flow conditions; generic GRGDS sequences; human breast cancer cells; new vasculature formation enhancement; targeted therapeutic imaging; tumor growth; Adhesives; Biomedical engineering; Biomedical imaging; Breast cancer; Humans; Peptides; Polymers; Programmable logic arrays; Sequences; Ultrasonic imaging;
Conference_Titel :
Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of
Print_ISBN :
0-7803-7767-2
DOI :
10.1109/NEBC.2003.1216043
