Title :
A high-throughput method of characterizing biomimetic surface modifications to basal lamina analogs for applications in tissue engineering
Author :
Tressel, Sarah L. ; Coughlan, Kristin A. ; Billiar, Kristen ; Pins, George
Author_Institution :
Dept. of Biomed. Eng., Worcester Polytech. Inst., MA, USA
Abstract :
The goal of this project is to develop tissue engineered skin substitutes with thin collagen membranes that mimic the basal lamina in native skin and promote keratinocyte attachment, migration, and proliferation. To achieve this goal we will conjugate basal lamina components to a membrane and we will characterize the relationship between extracellular matrix composition of basal lamina analogs and keratinocyte function.
Keywords :
biological tissues; biomedical materials; biomembranes; biomimetics; cellular biophysics; proteins; skin; basal lamina analogs; basal lamina components; extracellular matrix composition; keratinocyte attachment; keratinocyte function; membrane; migration; native skin basal lamina mimics; proliferation; skin ailments; skin burns; thin collagen membranes; tissue engineered skin substitutes; Biological materials; Biomedical engineering; Biomembranes; Biomimetics; Extracellular; Injuries; Regeneration engineering; Skin; Tissue engineering; Wounds;
Conference_Titel :
Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of
Print_ISBN :
0-7803-7767-2
DOI :
10.1109/NEBC.2003.1216061
