Computational modeling of drug delivery by microvascular networks

Author

Goldman, D.

Author_Institution

Math. Sci. & Biomed. Eng., New Jersey Inst. of Technol., Newark, NJ, USA

fYear

2003

Firstpage

321

Lastpage

322

Abstract

We have previously developed general computational models for studying blood flow and oxygen transport in complex microvascular networks. Here we describe how these models can be used to study delivery of other chemical species such as therapeutic drugs. We first describe our model of microvascular blood flow and a three-dimensional, time-dependent transport model applicable when the species of interest is carried mainly in dissolved form in the blood and the systemic concentration is fixed. We then present results of numerical simulations of blood flow in a constructed three-dimensional capillary network. Finally, we perform simulations of mass transport in the network and present results indicating the spatial heterogeneity of the concentration in the tissue.

Keywords

biotransport; cardiovascular system; haemorheology; muscle; partial differential equations; patient treatment; physiological models; computational modeling; drug concentration; drug delivery; microvascular blood flow; microvascular networks; spatial heterogeneity; therapeutic drugs; three-dimensional capillary network; three-dimensional time-dependent transport model; Biomedical engineering; Blood flow; Boundary conditions; Cells (biology); Computational modeling; Computer networks; Drug delivery; Equations; Immune system; Viscosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of

Print_ISBN

0-7803-7767-2

Type

conf

DOI

10.1109/NEBC.2003.1216125

Filename

1216125