Effect of polymer composition on ultrasound contrast agent performance

Author

Carine, Ehren T. ; Lathia, Justin D. ; El-Sherif, D. ; Wheatley, Margaret A.

Author_Institution

Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA

fYear

2003

Firstpage

331

Lastpage

332

Abstract

Polymer composition was evaluated for its contribution to the acoustic enhancement with a polymeric ultrasound contrast agent using poly (co-lactic-glycolic) acid (PLGA). Contrast agents were prepared from two different polymer compositions with varying ratios of lactic (LA) to glycolic acid (GA) (LA:GA): 100:0 and 50:50 and tested in vitro at room temperature and 37°C. The results indicate that the 100:0 sample preformed better than the 50:50 sample and was able to withstand further processing. The performance of the contrast agents was dependent on the ratio of LA to GA and should be considered in the design of polymeric contrast agents.

Keywords

biomedical materials; biomedical ultrasonics; polymers; 37 C; glycolic acid; lactic acid; medical diagnostic imaging; poly (co-lactic-glycolic) acid; polymer composition effect; polymeric contrast agents design; room temperature; ultrasound contrast agent performance; Acoustic testing; Biomedical acoustics; Biomedical engineering; Cancer; Chemical engineering; Peptides; Polymers; Temperature; Time factors; Ultrasonic imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of

Print_ISBN

0-7803-7767-2

Type

conf

DOI

10.1109/NEBC.2003.1216130

Filename

1216130