Title :
Effect of polymer composition on ultrasound contrast agent performance
Author :
Carine, Ehren T. ; Lathia, Justin D. ; El-Sherif, D. ; Wheatley, Margaret A.
Author_Institution :
Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA
Abstract :
Polymer composition was evaluated for its contribution to the acoustic enhancement with a polymeric ultrasound contrast agent using poly (co-lactic-glycolic) acid (PLGA). Contrast agents were prepared from two different polymer compositions with varying ratios of lactic (LA) to glycolic acid (GA) (LA:GA): 100:0 and 50:50 and tested in vitro at room temperature and 37°C. The results indicate that the 100:0 sample preformed better than the 50:50 sample and was able to withstand further processing. The performance of the contrast agents was dependent on the ratio of LA to GA and should be considered in the design of polymeric contrast agents.
Keywords :
biomedical materials; biomedical ultrasonics; polymers; 37 C; glycolic acid; lactic acid; medical diagnostic imaging; poly (co-lactic-glycolic) acid; polymer composition effect; polymeric contrast agents design; room temperature; ultrasound contrast agent performance; Acoustic testing; Biomedical acoustics; Biomedical engineering; Cancer; Chemical engineering; Peptides; Polymers; Temperature; Time factors; Ultrasonic imaging;
Conference_Titel :
Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of
Print_ISBN :
0-7803-7767-2
DOI :
10.1109/NEBC.2003.1216130
