Title :
Functionalized nanophase hydroxyapatite (HA) for orthopedic applications
Author :
Bhardwaj, Garima ; Webster, Thomas J.
Author_Institution :
Dept. of Chem. Eng., Northeastern Univ., Boston, MA, USA
Abstract :
Orthopedic implants fail due to various reasons such as extensive bacterial colonization, poor osseointegration, extensive inflammation and osteolysis due to wear debris. In order to reduce orthopedic implant failures, the main objective of this study was to create a biomimetic bone tissue engineering material based on the osteoconductive properties of nanophase hydroxyapatite (HA), the bacterial inhibition properties of the MAM7 peptide1, the quorum sensing inhibitor RNAIII peptide2, and the anticancer properties of the PCK3145 peptide3 as well as curcumin4. Results showed promise for these materials to combat common failure modes of orthopedic implants.
Keywords :
RNA; antibacterial activity; bioceramics; biomimetics; bone; calcium compounds; cancer; failure (mechanical); nanomedicine; orthopaedics; prosthetics; tissue engineering; wear; HA; MAM7 peptide1; PCK3145 peptide; anticancer properties; bacterial inhibition properties; biomimetic bone tissue engineering material; common failure modes; curcumin; extensive bacterial colonization; extensive inflammation; functionalized nanophase hydroxyapatite; orthopedic applications; orthopedic implant failures; orthopedic implants; osseointegration; osteoconductive properties; osteolysis; quorum sensing inhibitor RNAIII peptide; wear debris; Adhesives; Implants; Microorganisms; Nanoparticles; Peptides; Plasmas; Surface treatment; Hydroxyapatite(HA); MAM7; PCK3145; RNAIII peptide; curcumin;
Conference_Titel :
Bioengineering Conference (NEBEC), 2014 40th Annual Northeast
Conference_Location :
Boston, MA
DOI :
10.1109/NEBEC.2014.6972730
