Functionalized nanophase hydroxyapatite (HA) for orthopedic applications

Author

Bhardwaj, Garima ; Webster, Thomas J.

Author_Institution

Dept. of Chem. Eng., Northeastern Univ., Boston, MA, USA

fYear

2014

fDate

25-27 April 2014

Firstpage

1

Lastpage

2

Abstract

Orthopedic implants fail due to various reasons such as extensive bacterial colonization, poor osseointegration, extensive inflammation and osteolysis due to wear debris. In order to reduce orthopedic implant failures, the main objective of this study was to create a biomimetic bone tissue engineering material based on the osteoconductive properties of nanophase hydroxyapatite (HA), the bacterial inhibition properties of the MAM7 peptide¹, the quorum sensing inhibitor RNAIII peptide², and the anticancer properties of the PCK3145 peptide³ as well as curcumin⁴. Results showed promise for these materials to combat common failure modes of orthopedic implants.

Keywords

RNA; antibacterial activity; bioceramics; biomimetics; bone; calcium compounds; cancer; failure (mechanical); nanomedicine; orthopaedics; prosthetics; tissue engineering; wear; HA; MAM7 peptide1; PCK3145 peptide; anticancer properties; bacterial inhibition properties; biomimetic bone tissue engineering material; common failure modes; curcumin; extensive bacterial colonization; extensive inflammation; functionalized nanophase hydroxyapatite; orthopedic applications; orthopedic implant failures; orthopedic implants; osseointegration; osteoconductive properties; osteolysis; quorum sensing inhibitor RNAIII peptide; wear debris; Adhesives; Implants; Microorganisms; Nanoparticles; Peptides; Plasmas; Surface treatment; Hydroxyapatite(HA); MAM7; PCK3145; RNAIII peptide; curcumin;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference (NEBEC), 2014 40th Annual Northeast

Conference_Location

Boston, MA

Type

conf

DOI

10.1109/NEBEC.2014.6972730

Filename

6972730