Optically thin cellular micro-impedance electrode design optimization

Optically thin micro-impedance electrodes have the potential to simultaneously provide optical microscopy measurements with electrical impedance data. Most optically thin electro-conductive films, however, do not provide the same sensitivity as industry standard gold electrodes. As a result, the electrode geometry must be carefully optimized to detect cellular adhesion and growth. By varying the working electrode and counter electrode geometries, the sensitivity to cellular attachment can be optimized. In addition, parasitic capacitances can be minimized by using small working electrodes and dielectric layers. Lead resistances were negligible. The results of this ongoing study demonstrate that one can manufacture optically thin electrodes that are capable of detecting cancer cell growth and adhesion.