The effects of molecular weight on viability within PEGDA hydrogel microspheres

Author

Falkowski, Ron ; Medini, Michael ; Olabisi, Ronke

Author_Institution

Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA

fYear

2014

fDate

25-27 April 2014

Firstpage

1

Lastpage

2

Abstract

Poly(ethylene glycol) diacrylate (PEGDA) is a polymer often used in tissue engineering as a hydrogel scaffold. We determined the cell viability of murine osteoblast cells microencapsulated in PEGDA hydrogels of various molecular weights. Microspheres ranged between 20-200 μm in radius, to avoid exceeding the diffusion limit of oxygen. Concurrent diffusion studies were performed for each molecular weight to assess the size of the molecules permitted access by the hydrogels. Results demonstrated higher cell viability in higher molecular weight PEGDA microspheres.

Keywords

biodiffusion; biomedical materials; cellular biophysics; encapsulation; hydrogels; molecular weight; patient treatment; polymers; tissue engineering; PEGDA hydrogel microspheres; PEGDA hydrogels; cell viability; concurrent diffusion studies; higher molecular weight PEGDA microspheres; hydrogel scaffold; microencapsulation; murine osteoblast cells; oxygen diffusion limit; poly(ethylene glycol) diacrylate; radius 20 mum to 200 mum; tissue engineering; Bovine; Encapsulation; Fluorescence; Mice; Polymers; Proteins; Tissue engineering; cell encapsulation; hydrogel; microspheres; tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference (NEBEC), 2014 40th Annual Northeast

Conference_Location

Boston, MA

Type

conf

DOI

10.1109/NEBEC.2014.6972785

Filename

6972785