Reducing cancer cell interactions with selenium nanocluster-coated PLLA

Solid tumor malignancies are most effectively treated by tumor resection, but recurrence at the resulting margins continues to present complications in recovery. Chemotherapeutics have been employed to eliminate any remaining cancer cells, but the resulting side effects are unfavorable and taxing on the body. Thus, we are investigating non-chemotherapeutic, nanofeatured polymer-based implants and their effects on cancer and stromal cell activity. Specifically, poly(l-lactic acid) (PLLA) cast films have been treated with selenium nanoparticles to both add nano-scale topography and to investigate the anti-cancer properties of selenium. Growth and activity of osteosarcoma and non-cancerous stromal cells were investigated. With more selenium, and thus nanoroughness, the cancer cells were less apt to adhere and proliferate than non-cancerous cells.