Biases affecting tumor uptake measurements in FDG-PET

Author

Soret, M. ; Riddell, C. ; Hapdey, S. ; Buvat, I.

Author_Institution

CHU Pitie- Salpetriere, INSERM, Paris, France

Volume

4

fYear

2001

fDate

6/23/1905 12:00:00 AM

Firstpage

2119

Lastpage

2123

Abstract

The influence of tumor diameter, tumor-to-background activity ratio, attenuation, spatial resolution, tumor location, tumor non-uniformity and spatial sampling on the biases affecting tumor-to-background activity ratio (TBR) estimates in FDG PET was studied using analytical simulations of an anthropomorphic phantom. Major parameters affecting the bias amplitudes appeared to be the tumor diameter, the tumor-to-background activity ratio, whether attenuation had been performed, the spatial resolution of the PET scanner and the spatial sampling used to define the anatomical regions of interest used for TBR estimation

Keywords

medical image processing; positron emission tomography; tumours; FDG-PET; PET scanner; anthropomorphic phantom; spatial resolution; spatial sampling; tumor diameter; tumor location; tumor uptake measurements; tumor-to-background activity ratio; Analytical models; Attenuation; Image reconstruction; Imaging phantoms; Lungs; Medical simulation; Neoplasms; Positron emission tomography; Sampling methods; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2001 IEEE

Conference_Location

San Diego, CA

ISSN

1082-3654

Print_ISBN

0-7803-7324-3

Type

conf

DOI

10.1109/NSSMIC.2001.1009242

Filename

1009242