Real-time multi-channel system for neural spikes acquisition and detection

A real-time multi-channel system for neural spikes acquisition and detection is presented in this paper. It incorporates self-designed micro-machined silicon recording probes, specific multi-channel biomedical amplifiers, analog-to-digital converters and a digital signal processor. The system can inspect 32 channels of neural signals, detect the spikes simultaneously, and display 1 channel of the original signals and 32 channels of detection results on the PC screen. The function of the system is verified in a saline environment and the accuracy of the spike detection is 95%. Such system can be used as a head stage for free-moving and long-term recording, and even closed-loop recording and stimulating applications.