Spore biomarker detection using a MEMS differential mobility spectrometer

Author

Davis, C.E. ; Kang, J.M. ; Dube, C.E. ; Borenstein, J.T. ; Nazarov, E.G. ; Miller, R.A. ; ZapataAM

Author_Institution

Charles Stark Draper Lab., Cambridge, MA, USA

Volume

2

fYear

2003

Firstpage

1233

Abstract

Early detection technologies permit quick characterization of a bioweapons threat and identification of a hoax that will minimize human casualties and reduce the time and financial burdens associated with containment, triage and clean up. In this paper, we demonstrate that distinctive biological markers are present in pyrolyzed Bacillus endospore samples and these volatile chemical signatures can be detected by differential ion mobility spectrometry (DMS). The known endospore biomarker 2,6-pyridine-dicarboxylic acid (dipicolinic acid) can be detected by our micromachined DMS device, and Bacillus spore biomarkers are detected by DMS after pyrolysis.

Keywords

biosensors; chemical sensors; microsensors; pyrolysis; 2,6-pyridine-dicarboxylic acid; Bacillus spore biomarkers; MEMS differential mobility spectrometer; biological markers; bioweapons threat; differential ion mobility spectrometry; human casualties; pyrolysis; pyrolyzed Bacillus endospore; spore biomarker detection; volatile chemical signatures; Biomarkers; Chemicals; Fungi; Laboratories; Magnetic analysis; Micromechanical devices; Pathogens; Spectroscopy; Testing; Weapons;

fLanguage

English

Publisher

ieee

Conference_Titel

TRANSDUCERS, Solid-State Sensors, Actuators and Microsystems, 12th International Conference on, 2003

Conference_Location

Boston, MA, USA

Print_ISBN

0-7803-7731-1

Type

conf

DOI

10.1109/SENSOR.2003.1216995

Filename

1216995