DocumentCode
1730200
Title
Remote switching of cellular activity using light through quantum dots
Author
Lugo, Katherine ; Miao, Xiaoyu ; Rieke, Fred ; Lin, Lih Y.
Author_Institution
Dept. of Electr. Eng., Univ. of Washington, Seattle, WA, USA
fYear
2010
Firstpage
67
Lastpage
68
Abstract
We report integration of CdTe quantum dot (QD) film with LnCap (prostate cancer) cell and CdSe QD probes with cortical neurons for control of cellular activity. We demonstrate the remote switching of cellular activity by exciting QDs with light. Changes in membrane potential and ionic currents are recorded using the patch-clamp method. Upon excitation, the cell shows activation of ion channels and hyperpolarization of the cell membrane.
Keywords
II-VI semiconductors; cadmium compounds; cancer; cellular biophysics; membranes; optical switches; semiconductor quantum dots; wide band gap semiconductors; CdSe; CdTe; cell membrane; cellular activity; cortical neurons; hyperpolarization; ionic currents; light quantum dots; membrane potential; patch-clamp method; prostate cancer cell; remote switching; Biomembranes; Electric potential; Films; Ions; Neurons; Probes; Quantum dots;
fLanguage
English
Publisher
ieee
Conference_Titel
Optical MEMS and Nanophotonics (OPT MEMS), 2010 International Conference on
Conference_Location
Sapporo
Print_ISBN
978-1-4244-8926-8
Electronic_ISBN
978-1-4244-8925-1
Type
conf
DOI
10.1109/OMEMS.2010.5672180
Filename
5672180
Link To Document