Title :
Simulation of thrombin generation during plasmatic coagulation and primary hemostasis
Author :
Ballet, Pascal ; Abgrall, Jean-François ; Rodin, Vincent ; Tisseau, Jacques
Author_Institution :
French Nat. Sch. of Eng., Brest, France
Abstract :
Describes a simulation of the platelet agglutination in a damaged vein. This agglutination, called plasmatic coagulation, appears in the human body and its malfunction involves dramatic diseases like thrombosis or hemophilia. We designed an in-machina experimentation that is very difficult to do in-vitro. The first aim of this simulation is to verify one of the biological models of plasmatic coagulation and primary hemostasis. The second aim is to test different ways to regulate the thrombin production. Then, we simulate a haemophilia-like disease and one of its possible treatments
Keywords :
blood; coagulation; digital simulation; diseases; medical computing; patient treatment; biological models; blood clotting; damaged vein; disease treatment; haemophilia; in-machina experimentation; malfunction; plasmatic coagulation; platelet agglutination; primary haemostasis; thrombin generation simulation; thrombin production regulation; thrombosis; Biological system modeling; Cells (biology); Coagulation; Computational modeling; Diseases; Immune system; In vitro; Laboratories; Plasma simulation; Proteins;
Conference_Titel :
Systems, Man, and Cybernetics, 2000 IEEE International Conference on
Conference_Location :
Nashville, TN
Print_ISBN :
0-7803-6583-6
DOI :
10.1109/ICSMC.2000.884977