Modeling linear-quadratic CFU survival parameters for daily fractionated radiation

Author

Zimmer, John ; Blazek, Ed R. ; Chu, James ; Saxena, V. Amod

Author_Institution

Dept. of Med. Phys., Rush Presbyterian St. Lukes Med. Center, Chicago, IL, USA

Volume

2

fYear

2000

fDate

2000

Firstpage

882

Abstract

Daily fractionated and graded dose assays simulate the dose and timing of standard external beam treatments. These assays measure the survival of a colony forming units (CFU) rather than cell survival per se. A spreadsheet is used to model these daily treatment assays in terms of (1) cell killing from individual exposures and (2) repopulation doubling times

Keywords

cellular effects of radiation; digital simulation; dosimetry; medical computing; physiological models; radiation therapy; spreadsheet programs; cell killing; cellular radiobiology; colony forming units; daily treatment assays; individual exposures; linear-quadratic CFU survival parameters modeling; repopulation doubling times; standard external beam treatments; treatment dose; treatments timing; tumor cells radiosensitivity; Equations; Fractionation; In vitro; Mathematical model; Measurement units; Medical treatment; Predictive models; Timing; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-6465-1

Type

conf

DOI

10.1109/IEMBS.2000.897858

Filename

897858