Title :
In situ optical biopsy with a confocal microendoscope
Author :
Gmitro, Arthur F. ; Rouse, Andrew R. ; Sabharwal, Y.S.
Author_Institution :
Dept. of Radiol., Arizona Univ., Tucson, AZ, USA
Abstract :
A confocal microendoscope for in situ optical biopsy has been developed. The system couples a slit-scan confocal fluorescence microscope to an optical catheter, consisting of a coherent fiber-optic imaging bundle, or a fiber bundle with a miniature objective and hydraulic focusing mechanism. The confocal microendoscope provides adequate image quality to visualize individual cells and subcellular structures. Vital fluorescent dyes are used with the system as selective stains for histopathologic evaluation of disease
Keywords :
bio-optics; biological tissues; biomedical imaging; cellular biophysics; fluorescence; optical fibres; optical images; optical microscopy; CCD camera; GRIN lens; coherent fiber-optic imaging bundle; confocal microendoscope; disease; fluorescent dyes; histopathologic evaluation; hydraulic focusing mechanism; in situ optical biopsy; individual cells visualisation; living tissues; miniature objective; optical catheter; selective stains; slit-scan confocal fluorescence microscope; subcellular structures; Biomedical optical imaging; Biopsy; Catheters; Fluorescence; Focusing; Image quality; Optical coupling; Optical imaging; Optical microscopy; Visualization;
Conference_Titel :
Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-6465-1
DOI :
10.1109/IEMBS.2000.897904
