Interaction of hemodynamics and gas exchange: a computer simulation

Author

Qiu, Anqi ; Bai, Jing

Author_Institution

Dept. of Electr. Eng. & Appl. Electron. Technol., Tsinghua Univ., Beijing, China

Volume

3

fYear

2000

fDate

2000

Firstpage

1923

Abstract

Presents a model concerning interaction of hemodynamics and gas exchange, which involves two physiological systems-respiratory and circulatory systems. It consists of five components: a model of gas transport, exchange and storage in the human, a multi-element nonlinear mathematical model of human circulatory system, an alveolar ventilation controller, a cardiac output controller, and a controller of frequency of breathing. Model simulations provided results of both dynamic and steady-state responses under low oxygen (hypoxia), which can reflect the interaction of hemodynamics and gas exchange. By using this model, the changes of pulmonary arterial pressure and right ventricular pressure in high altitude, which may cause mountain sickness, are discussed. Therefore, this model may be used to study reaction of hypoxia and the assist technologies

Keywords

biocontrol; controllers; digital simulation; haemodynamics; medical computing; physiological models; pneumodynamics; alveolar ventilation controller; assist technologies; breathing frequency controller; cardiac output controller; hemodynamics-gas exchange interaction; high altitude; hypoxia; low oxygen; mountain sickness; multi-element nonlinear mathematical model; pulmonary arterial pressure; right ventricular pressure; Circulatory system; Computer simulation; Frequency; Hemodynamics; Humans; Mathematical model; Nonlinear control systems; Nonlinear dynamical systems; Steady-state; Ventilation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-6465-1

Type

conf

DOI

10.1109/IEMBS.2000.900468

Filename

900468