Rind-therapy: a new approach to treatment and management of larger brain lesions

We present a new technique, `rind-therapy´, for the treatment and management of larger brain lesions, where the goal is management rather than cure. The technique achieves boosting the dose to rapidly proliferating tumour tissue at the periphery of the lesion, by delivering lower dose to the poorly perfused and invariably necrotic tumour core. Rind-therapy therefore directly addresses the dominant clinical issue for many such patients, that of arresting the rapidly proliferating tumour tissue located in the well-oxygenated and well supplied periphery of the lesion. The aim is to boost the peripheral dose to effective levels whilst maintaining the dose to normal brain within tolerance, and maintaining low volume receiving high dose. Arresting the proliferation in this manner may open a `window of opportunity´ for other treatment modalities