Hyperpolarized xenon relaxation times in perfluorocarbon emulsion and plasma mixtures

Author

Cross, Albert R. ; McPhee, Dan ; Stevens, Dale ; McDonald, Mark ; Santyr, Giles E.

Author_Institution

Dept. of Phys., Carleton Univ., Ottawa, Ont., Canada

Volume

3

fYear

2000

fDate

2000

Firstpage

2171

Abstract

Hyperpolarized xenon (Hyp-¹²⁹Xe) has great potential in perfusion, blood flow and functional investigations of organs beyond the lungs. Injection of xenon in a dissolved carrier would be the best delivery method for this purpose. The blood substitute perfluorooctyl bromide (PFOB) emulsion is the leading candidate as a carrier. To assess the suitability of PFOB emulsion as a Hyp-¹²⁹Xe carrier, spectra of Hyp-¹²⁹Xe in plasma, PFOB, and plasma-PFOB mixtures have been recorded. Longitudinal relaxation (T₁) measurements have been made. The T₁ was found to be about 6 s in plasma, 108±5 s in PFOB emulsion and 18±4 s in a mixture of 60% PFOB and 40% plasma. The relaxation time in the PFOB-plasma mixture is enhanced compared to plasma alone however there is a significant reduction in T₁

Keywords

biomedical MRI; blood flow measurement; emulsions; haemorheology; nuclear polarisation; nuclear spin-lattice relaxation; Hyp-¹²⁹Xe carrier; blood flow; dissolved carrier; functional investigations; hyperpolarized xenon relaxation times; longitudinal relaxation; organs; perfluorocarbon emulsion; perfluorooctyl bromide emulsion; perfusion; plasma mixtures; xenon injection; Blood; Gas lasers; Helium; Lipidomics; Magnetization; Plasma measurements; Plasma properties; Polarization; Semiconductor laser arrays; Xenon;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1094-687X

Print_ISBN

0-7803-6465-1

Type

conf

DOI

10.1109/IEMBS.2000.900561

Filename

900561