Title :
Hyperpolarized xenon relaxation times in perfluorocarbon emulsion and plasma mixtures
Author :
Cross, Albert R. ; McPhee, Dan ; Stevens, Dale ; McDonald, Mark ; Santyr, Giles E.
Author_Institution :
Dept. of Phys., Carleton Univ., Ottawa, Ont., Canada
Abstract :
Hyperpolarized xenon (Hyp-129Xe) has great potential in perfusion, blood flow and functional investigations of organs beyond the lungs. Injection of xenon in a dissolved carrier would be the best delivery method for this purpose. The blood substitute perfluorooctyl bromide (PFOB) emulsion is the leading candidate as a carrier. To assess the suitability of PFOB emulsion as a Hyp-129Xe carrier, spectra of Hyp-129Xe in plasma, PFOB, and plasma-PFOB mixtures have been recorded. Longitudinal relaxation (T1) measurements have been made. The T1 was found to be about 6 s in plasma, 108±5 s in PFOB emulsion and 18±4 s in a mixture of 60% PFOB and 40% plasma. The relaxation time in the PFOB-plasma mixture is enhanced compared to plasma alone however there is a significant reduction in T1
Keywords :
biomedical MRI; blood flow measurement; emulsions; haemorheology; nuclear polarisation; nuclear spin-lattice relaxation; Hyp-129Xe carrier; blood flow; dissolved carrier; functional investigations; hyperpolarized xenon relaxation times; longitudinal relaxation; organs; perfluorocarbon emulsion; perfluorooctyl bromide emulsion; perfusion; plasma mixtures; xenon injection; Blood; Gas lasers; Helium; Lipidomics; Magnetization; Plasma measurements; Plasma properties; Polarization; Semiconductor laser arrays; Xenon;
Conference_Titel :
Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-6465-1
DOI :
10.1109/IEMBS.2000.900561
