DocumentCode :
1741391
Title :
Simulated dynamic interaction of coupled sinoatrial node pacemaker cell pairs
Author :
Cloherty, Shaun ; Lovell, Nigel ; Celler, Branko ; Dokos, Socrates
Author_Institution :
Graduate Sch. of Biomed. Eng., New South Wales Univ., Kensington, NSW, Australia
Volume :
1
fYear :
2000
fDate :
2000
Firstpage :
395
Abstract :
Previous modelling studied by other investigators indicates that electrotonic coupling between cells underlies mutual entrainment and synchronization of the intact sinus node. In this study, interaction between a pair of resistively coupled pacemaker cells was investigated using a complex, physiologically accurate model of the single sinoatrial node cell. Variation in intrinsic cycle length was achieved by multiplying the background sodium conductance gb,Na by a constant modulating parameter (0<α⩽1.0). For each value of the modulating parameter a single cell was integrated until a steady state was achieved, at which point the model parameters were saved for use as initial conditions in the simulations of coupled cell pairs. The effect of cycle length and magnitude of coupling resistance on entrainment were investigated. Simulation results are presented demonstrating both simple and complex entrainment phenomena
Keywords :
cardiology; cellular biophysics; neurophysiology; physiological models; Na; background sodium conductance; complex entrainment phenomena; complex physiologically accurate model; constant modulating parameter; coupled sinoatrial node pacemaker cell pairs; electrotonic coupling between cells; model parameters; mutual entrainment; resistively coupled pacemaker cells; simple entrainment phenomena; simulated dynamic interaction; Australia; Biomembranes; Computational modeling; Equations; Frequency synchronization; Immune system; Mutual coupling; Pacemakers; Rabbits; Steady-state;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2000. Proceedings of the 22nd Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
ISSN :
1094-687X
Print_ISBN :
0-7803-6465-1
Type :
conf
DOI :
10.1109/IEMBS.2000.900758
Filename :
900758
Link To Document :
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