Design Considerations for CMOS-Integrated Hall-Effect Magnetic Bead Detectors for Biosensor Applications

Author

Skucha, K. ; Gambini, Simone ; Liu, Peng ; Megens, M. ; Kim, Jung-Ho ; Boser, Bernhard E.

Author_Institution

Electr. Eng. Dept., Univ. of California, Berkeley, Berkeley, CA, USA

Volume

22

Issue

6

fYear

2013

fDate

Dec. 2013

Firstpage

1327

Lastpage

1338

Abstract

We describe a design methodology for on-chip magnetic bead label detectors based on Hall-effect sensors. Signal errors caused by the label-binding process and other factors that limit the minimum detection area are quantified and adjusted to meet typical assay accuracy standards. The methodology is demonstrated by designing an 8192 element Hall sensor array, implemented in a commercial 0.18 μm CMOS process with single-mask postprocessing. The array can quantify a 1% surface coverage of 2.8 μm beads in 30 seconds with a coefficient of variation of 7.4%. This combination of accuracy and speed makes this technology a suitable detection platform for biological assays based on magnetic bead labels.

Keywords

CMOS integrated circuits; Hall effect transducers; biosensors; detector circuits; magnetic sensors; readout electronics; sensor arrays; CMOS integrated circuit; Hall effect magnetic bead detectors; Hall effect sensor; Hall sensor array; assay accuracy standard; biosensor applications; label binding process; on-chip magnetic bead label detector; signal errors; single mask postprocessing; size 0.18 mum; Assay; CMOS; Hall-effect; biosensor; magnetic bead; magnetic particle;

fLanguage

English

Journal_Title

Microelectromechanical Systems, Journal of

Publisher

ieee

ISSN

1057-7157

Type

jour

DOI

10.1109/JMEMS.2013.2259615

Filename

6524013