Body on a Chip: Re-Creation of a Living System In Vitro

Body on a chip could contribute to human health and be an extremely useful application in nano/microengineering. However, in reality, body on a chip is still at the proof-of-concept stage, such as in terms of the placement of multiple tissues within a single device, and much effort is required for its development into a practical and useful technology. To achieve this goal, it is necessary to advance individual technologies such as micro/nanoengineering, tissue engineering, and stem cell manipulations and the integration of these technologies. This means that the development of body on a chip requires interdisciplinary research and, if achieved, it would not only represent a vast advancement in drug discovery but would also increase our understanding of specific disease mechanisms. In particular, in conjunction with hPSCs, which are specified for rare diseases, body on a chip will serve as a new platform to study unsolved and unstudied mechanisms of rare diseases and provide cures for such diseases.