Title :
Biosensor systems and applications in genomics, proteomics and metabolomics: A review
Author :
MacKay, Scott ; Jie Chen
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Alberta, Edmonton, AB, Canada
Abstract :
This article provides a brief overview and background on current biosensor designs for applications in genomics, proteomics and metabolomics. As research continues in many different aspects of biosensor design, new and better ways to recognize and detect low concentrations of a wide variety of different biomolecules are being developed for various applications. Biosensors can offer a simpler, faster and cheaper alternative to the testing that is often required to collect the large amounts of data for genomic, proteomic and metabolomic sensing. Recognition elements such as DNA aptamers make detecting very different types of biomolecules in the same system possible, while the use of signal-enhancing nanoparticle probes and microfabricated sensor arrays make it possible to test for a large number of different target biomolecules quickly and effectively.
Keywords :
DNA; biosensors; genomics; microsensors; nanoparticles; nanosensors; proteomics; DNA aptamers; biomolecule detection; biosensor designs; biosensor systems; genomic sensing; metabolomic sensing; microfabricated sensor arrays; proteomic sensing; recognition elements; signal-enhancing nanoparticle probes; target biomolecules; Biosensors; DNA; Electrodes; Gold; Molecular biophysics; Nanoparticles; Target recognition; Antibody; Aptamer; Biosensor; Carbon nanotube; Electrochemical detection; Genomics; Mass based detection; Optical detection; Proteomics and Metabolomics; RNA/DNA; SELEX;
Conference_Titel :
Circuits and Systems (ISCAS), 2014 IEEE International Symposium on
Conference_Location :
Melbourne VIC
Print_ISBN :
978-1-4799-3431-7
DOI :
10.1109/ISCAS.2014.6865104