Author :
Xilin Liu ; Subei, Basheer ; Milin Zhang ; Richardson, Andrew G. ; Lucas, Timothy H. ; Van der Spiegel, Jan
Author_Institution :
Dept. of Electr. & Syst. Eng., Univ. of Pennsylvania, Philadelphia, PA, USA
Abstract :
In this paper, a general purpose wireless Brain-Machine-Brain Interface (BMBI) system is proposed. The system provides all the necessary hardware for a closed-loop sensorimotor neural interface. The system integrates a neural signal analyzer, two neural stimulators with different specifications, multiple body area sensory devices and a user-friendly computer interface. The neural signal analyzer features four channel analog frontend with configurable bandpass filter, gain stage, digitization resolution, and sampling rate. Digital filtering, neural feature extraction, spike detection, sensing-stimulating modulation, and compressed sensing measurement are realized in a central processing unit integrated in the analyzer. Flash memory card is activated for low power operation, compressed sensing recovery verification and/or data backup. An 8-channel stimulator with high driving capability (±10 mA with compliance voltage ±22V), and a 2-channel stimulator for deep brain stimulation are included in the proposed system. Both stimulators are capable of delivering bipolar, biphasic capacitive coupled current pulses in programmable pulse shape, amplitude, width, pulse train frequency and latency. Multi-functional wireless sensor node, including an accelerometer, a temperature sensor, and a general sensor extension port has been designed. Surveillance camera is implemented for the monitoring of the animal´s behavior. A userfriendly computer interface is designed to monitor, control and configure all aforementioned devices via wireless link. Wireless closed-loop operation between the sensory devices, neural stimulators, and neural signal analyzer can be configured. Bench test and in vivo experiments are performed to verify the functions and performance of the system.
Keywords :
accelerometers; band-pass filters; bioelectric potentials; biomedical electronics; biomedical optical imaging; biomedical telemetry; biothermics; body sensor networks; brain; brain-computer interfaces; cameras; closed loop systems; compressed sensing; digital filters; feature extraction; human computer interaction; medical control systems; medical signal detection; medical signal processing; neurophysiology; patient treatment; temperature sensors; 2-channel stimulator; 8-channel stimulator; PennBMBI; accelerometer; animal behavior monitoring; bench test; biphasic capacitive coupled current pulse delivery; bipolar current pulse delivery; central processing unit integration; closed-loop sensorimotor neural interface; compliance voltage; compressed sensing measurement; compressed sensing recovery verification; configurable bandpass filter; data backup; deep brain stimulation; device configuration; device control; device monitoring; digital filtering; digitization resolution; driving capability; flash memory card activation; four-channel analog frontend; gain stage; general purpose wireless BMBI system; general purpose wireless brain-machine-brain interface system; general sensor extension port; hardware; in vivo experiments; low power operation; multifunctional wireless sensor node; multiple body area sensory devices; neural feature extraction; neural signal analyzer; neural stimulator specifications; neural stimulators; programmable pulse amplitude; programmable pulse shape; programmable pulse width; pulse train frequency; pulse train latency; sampling rate; sensing-stimulating modulation; spike detection; surveillance camera; temperature sensor; unrestrained animals; user-friendly computer interface; userfriendly computer interface design; wireless closed-loop operation; wireless link; Compressed sensing; Current measurement; Graphical user interfaces; Hardware; Performance evaluation; Wireless communication; Wireless sensor networks; Brain-Machine-Brain Interface (BMBI); closed-loop; neural recording; neural stimulation;
