Title :
NIR fluorescent contrast agents for detection of inflammation of lungs in vivo
Author :
Haiying Zhou ; Shawn He ; Gunsten, Sean ; Brody, Steven ; Akers, Walter ; Berezin, Mikhail Y.
Author_Institution :
Sch. of Med., Dept. of Radiol., Washington Univ., St. Louis, MO, USA
Abstract :
Inflammatory responses to lung injuries are mediated through enhanced production of reactive oxygen species (ROS). We describe the use of activatable NIR fluorescent agents with high sensitivity to ROS to image the lung during conditions of high inflammation.
Keywords :
biochemistry; biomedical optical imaging; fluorescence; infrared imaging; injuries; lung; oxygen; NIR fluorescent contrast agent; O2; ROS production enhancement; ROS sensitivity; activatable NIR fluorescent agent; in vivo lung inflammation detection; inflammatory response; lung imaging; lung injury; reactive oxygen species; Fluorescence; Imaging; In vivo; Lungs; Mice; Probes; Sensitivity;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2014 Conference on
Conference_Location :
San Jose, CA
