Nonlinear two stage mechanotransduction model and neural response of Pacinian Corpuscle

Author

Biswas, Arijit ; Manivannan, M. ; Srinivasan, M.A.

Author_Institution

Dept. of Appl. Mech., IIT Madras, Chennai, India

fYear

2014

fDate

6-8 May 2014

Firstpage

1

Lastpage

4

Abstract

This paper presents a biomechanical and neurophysiological model of skin and Pacinian Corpuscle (PC) to simulate its neural response over few 10s of Hz to 2000 Hz obtained from experiments. The PC neural responses are studied with sinusoidal stimuli to elucidate the relation between receptor potential and action potential and its variabilities. The overall model includes mechanical signal conditioning in both skin-layers and PC-lamellae, electro-mechanical transduction in the inner core of PC, followed by an improved Adaptive Relaxation Pulse Frequency Modulation (ARPFM). This model can be extended to simulate a group of PCs including many other variabilities in PC which will help in enhancing the technologies related to perception of vibration.

Keywords

bioelectric potentials; biomechanics; electromechanical effects; neurophysiology; pulse frequency modulation; skin; vibrations; ARPFM; PC neural responses; action potential; adaptive relaxation pulse frequency modulation; biomechanical model; electromechanical transduction; mechanical signal conditioning; neurophysiological model; nonlinear two-stage mechanotransduction model; pacinian corpuscle; receptor potential; sinusoidal stimuli; skin; time 10 s; vibration perception; Adaptation models; Biological system modeling; Biomechanics; Charge transfer; Electric potential; Generators; Skin; Neurophysiology; Receptor Potential; Spike Rate;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Science and Engineering Center Conference (BSEC), 2014 Annual Oak Ridge National Laboratory

Conference_Location

Oak Ridge, TN

Type

conf

DOI

10.1109/BSEC.2014.6867740

Filename

6867740