Title :
Detection of single nanoparticles using photonic crystal enhanced microscopy
Author :
Yue Zhuo ; Huan Hu ; Weili Chen ; Meng Lu ; Limei Tian ; Hojeong Yu ; Long, Kenneth D. ; Chow, Edmond ; King, William P. ; Singamaneni, Srikanth ; Cunningham, Brian T.
Author_Institution :
Dept. of Bioeng., Univ. of Illinois at Urbana-Champaign, Champaign, IL, USA
Abstract :
We demonstrate a label-free biosensor imaging approach that utilizes a photonic-crystal surface to detect attachment of individual nanoparticles down to ~65×30×30nm3. Matching nanoparticle plasmon resonant-frequency to the photonic-crystal resonance substantially increases sensitivity of the approach.
Keywords :
biomedical optical imaging; biosensors; nanomedicine; nanoparticles; nanosensors; optical microscopy; optical sensors; photonic crystals; plasmons; label-free biosensor imaging approach; nanoparticle plasmon resonant-frequency; photonic crystal-enhanced microscopy; photonic-crystal resonance; photonic-crystal surface; single nanoparticle detection; Biosensors; Educational institutions; Nanoparticles; Optical surface waves; Photonic crystals; Surface waves;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2014 Conference on
Conference_Location :
San Jose, CA
