Stacked Sparse Autoencoder (SSAE) based framework for nuclei patch classification on breast cancer histopathology

In this paper, a Stacked Sparse Autoencoder (SSAE) based framework is presented for nuclei classification on breast cancer histopathology. SSAE works very well in learning useful high-level feature for better representation of input raw data. To show the effectiveness of proposed framework, SSAE+Softmax is compared with conventional Softmax classifier, PCA+Softmax, and single layer Sparse Autoencoder (SAE)+Softmax in classifying the nuclei and non-nuclei patches extracted from breast cancer histopathology. The SSAE+Softmax for nuclei patch classification yields an accuracy of 83.7%, F1 score of 82%, and AUC of 0.8992, which outperform Softmax classifier, PCA+Softmax, and SAE+Softmax.