DocumentCode
1777789
Title
Quantitative analysis of brain SPECT with 99mTc-HMPAO in patients with mild cognitive changes
Author
Nikolov, N.A. ; Zalisna, Yu.D. ; Makeyev, S.S. ; Loshickij, P.P. ; Yaroshenko, O.Yu. ; Supruniuk, D.A.
Author_Institution
Dept. of Phys. & Biomed. Electron., Nat. Tech. Univ. of Ukraine “KPI”, Kiev, Ukraine
fYear
2014
fDate
15-18 April 2014
Firstpage
295
Lastpage
298
Abstract
Mild cognitive disorders in patients is often not accompanied by focal changes in brain regions, which significantly complicates the objective assessment of pathology. Therefore, a new approach of quantitative analysis of brain single-photon emission computed tomography is developed. The analysis is based on calculating the average gradient of radioactivity distribution in a brain cross-section along a predetermined direction, as well as on Fourier spectra analysis, which are characterized by "1/f" (flicker noise) type behavior. Pilot clinical study of six patients shows promising prospects of the developed method.
Keywords
Fourier analysis; brain; cognition; flicker noise; medical disorders; single photon emission computed tomography; technetium; 1/f flicker noise-type behavior; 99mTc-HMPAO; Fourier spectra analysis; average gradient calculation; brain SPECT; brain regions; brain single-photon emission computed tomography; mild cognitive disorders; objective pathology assessment; quantitative analysis; radioactivity distribution; 1f noise; Conferences; Diseases; Lesions; Linear approximation; Single photon emission computed tomography; Synchronization; SPECT; brain; cognitive disorders; homeostasis; quantitative analysis of image; sinhronization;
fLanguage
English
Publisher
ieee
Conference_Titel
Electronics and Nanotechnology (ELNANO), 2014 IEEE 34th International Conference on
Conference_Location
Kyiv
Print_ISBN
978-1-4799-4581-8
Type
conf
DOI
10.1109/ELNANO.2014.6873455
Filename
6873455
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