The effect of the inhomogeneous magnetic fields on the antitumor activity of magnetic nanotherapy

Author

Orel, V.E. ; Dzyatkovskaya, N.N. ; Kruchkov, E.I. ; Nikolov, N.A. ; Rykhalskiy, A.Y. ; Romanov, A.V. ; Penievskyi, M.I. ; Radaguz, A.V.

Author_Institution

Med. Phys. & Bioeng. Dept., Nat. Cancer Inst., Kiev, Ukraine

fYear

2014

fDate

15-18 April 2014

Firstpage

329

Lastpage

333

Abstract

In the research of animals with carcinosarcoma Walker-256 was shown, that magnetic nanocomplex on the basis of nanoparticles of Fe₃O₄ with antitumor anthracycline row antibiotic doxorubicin and next local electromagnetic irradiation by spatially inhomogeneous constant magnetic and variable electromagnetic fields had nonlinear effect on growth tumor volume in the direction of strengthening and inhibition tumor size. The radio frequency mild hyperthermia and magneto-sensitive nanocomplex increased antitumor effect up to 16% as compared to conventional doxorubicin.

Keywords

antibacterial activity; hyperthermia; iron compounds; nanomagnetics; nanomedicine; nanoparticles; patient treatment; tumours; Fe₃O₄; Fe₃O₄ nanoparticles; antitumor activity; antitumor anthracycline row antibiotic doxorubicin; carcinosarcoma Walker-256; inhibition tumor size; inhomogeneous magnetic field effect; local electromagnetic irradiation; magnetic nanocomplex; magnetic nanotherapy; magnetosensitive nanocomplex; nonlinear effect; radiofrequency mild hyperthermia; spatially inhomogeneous constant magnetic fields; spatially inhomogeneous variable electromagnetic fields; tumor size strengthening; tumor volume growth; Cancer; Magnetic fields; Magnetic flux; Magnetomechanical effects; Nanoparticles; Saturation magnetization; Tumors; magnetic field; magnetic nanocomplex; magnetic-dipole applicator; tumor;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronics and Nanotechnology (ELNANO), 2014 IEEE 34th International Conference on

Conference_Location

Kyiv

Print_ISBN

978-1-4799-4581-8

Type

conf

DOI

10.1109/ELNANO.2014.6873909

Filename

6873909