Platform for the modeling of in vivo effects relevant to implant EM exposure safety

The safety assessment of implant EM exposure is typically performed by numerically or experimentally evaluating field strengths in (frequently strongly simplified) phantoms or anatomical models. Determining quantities more closely related to the effect of concern can aid in detecting insufficient safety margins, reducing the necessity for overly conservative limits, and increasing the understanding of the mechanisms. SIM4LIFE is a multiphysics simulation platform optimized for computational life sciences with strong support for image based modeling and simulations involving complex anatomical models, offering solvers optimized for the modeling of living tissue, including biological and physiological processes. In the context of implant EM exposure safety, particularly under MR imaging, the platform offers powerful functionality for the modeling of the exposure, but also for the investigation of the induced effects. Tools to study induced heating (considering perfusion and thermoregulation), thermal dose, tissue damage estimation, and EM induced neuronal dynamics are presented here.