VISWES: A system for finding related vaccinia virus protein sequences in cancer immune therapy

Author

SeungHeui Ryu ; NaHyun Kwak ; DoHoon Lee

Author_Institution

Dept. of Comput. Sci. & Eng., Pusan Nat. Univ., Pusan, South Korea

fYear

2014

fDate

2-5 Nov. 2014

Firstpage

285

Lastpage

288

Abstract

The use of vaccinia virus, an oncolytic virus, in cancer immune therapy enhances the overall immune response. The mechanism of immune response against cancer and virus infection is similar. We found sequence relationships between vaccinia virus proteins and human proteins that are often regarded as hallmarks of cancer. From comparing human and vaccinia virus protein sequences, genetically engineered viruses associated with immune response have been used for cancer immune therapy in many clinical trials. Using published papers about cancer immunology, we classified proteins as either positively or negatively associated with cancer immune therapy. We searched for sequence relationships between human proteins and vaccinia virus proteins that are related to the classified proteins.

Keywords

associative processing; biochemistry; bioinformatics; cancer; classification; data mining; genetic engineering; macromolecules; medical computing; microorganisms; molecular biophysics; molecular configurations; patient treatment; pattern matching; proteins; sequences; VISWES; cancer hallmark; cancer immune therapy; cancer immunology; cancer response mechanism; clinical trial; human protein; immune response enhancement; immune response mechanism; negative association; oncolytic virus; positive association; protein classification; protein sequence comparison; protein sequence relationship; related vaccinia virus protein sequence search; virus genetic engineering; virus infection response mechanism; Cancer; Immune system; Medical treatment; Proteins; Tumors; Viruses (medical); Visualization; cancer therapy; immune response; oncolytic virus; protein; sequence analyse;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedicine (BIBM), 2014 IEEE International Conference on

Conference_Location

Belfast

Type

conf

DOI

10.1109/BIBM.2014.6999169

Filename

6999169