Title :
Proarrhythmic effects of cisapride: Insights from a simulation study
Author :
Yongfeng Yuan ; Songjun Xie ; Kuanquan Wang ; Henggui Zhang
Author_Institution :
Sch. of Comput. Sci. & Technol., Harbin Inst. of Technol., Harbin, China
Abstract :
Cisapride as a prokinetic drug inhibits rapid delayed rectifier potassium channel current. As producing QT interval prolongation and causes fatal cardiac arrhythmias, it has been withdrawn from clinical uses. However, exact mechanisms for the proarrhythmic effects of cisapride are incompletely unclear. In this study, we implemented a biophysically detailed computational model of the heart to quantify the effects of the cisapride on cardiac electrical activities at cellular and tissue levels, from which we analyzed the proarrhythmic effects of the agent.
Keywords :
diseases; drugs; electrocardiography; QT interval prolongation; cardiac electrical activity; cellular level; cisapride; fatal cardiac arrhythmias; heart; potassium channel current; proarrhythmic effects; prokinetic drug; rapid delayed rectifier; tissue level; Biological system modeling; Computational modeling; Drugs; Electric potential; Electrocardiography; Heart; Mathematical model; cisapride; computational model; drug safety assessment;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2014 IEEE International Conference on
Conference_Location :
Belfast
DOI :
10.1109/BIBM.2014.6999258
