Title :
Drug resistance gene identification algorithm for next-generation sequencing data
Author :
Guan-Jie Hua ; Che-Lun Hung ; Chuan Yi Tang ; Huiru Zheng
Author_Institution :
Dept. Comput. Sci., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
In the 21st century, antibiotic resistance has become a crucial and growing phenomenon in contemporary medicine. Multidrug resistant leads that antibiotics cannot be used to treat infections. In this paper, we propose a novel and efficient method to identify drug resistance genes from raw reads produced by next generation sequencing technology for metagenomes. The experimental results show that the proposed method is able to identify the resistance genes of Acinetobacter baumannii, TYTH-1.
Keywords :
bioinformatics; drugs; genetics; genomics; microorganisms; Acinetobacter baumannii TYTH-1; antibiotic resistance; contemporary medicine; drug resistance gene identification algorithm; infections; metagenomes; multidrug resistance; next-generation sequencing data; Antibiotics; Bioinformatics; DNA; Databases; Immune system; Microorganisms; Sequential analysis; Assembly; Drug Resistance; Integron; Metagenomics; Next Generation Sequencing;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2014 IEEE International Conference on
Conference_Location :
Belfast
DOI :
10.1109/BIBM.2014.6999381