Realistic cell and organelle shape modeling for computational bioengineering: A new open-source toolbox

This paper describes a new, open-source Matlab toolbox, which can be used to directly build realistic, complex geometrical models of irregular biological cell shapes and organelles based on user definitions on single two-dimensional micrographs. The main advantages are flexibility and versatility as needed for irregular cell shape modeling for computational bioelectrical and biomechanical studies, which are not met in conventional computer modeling tools. The algorithms, results and applications are briefly described. Specifically as shown, the software can be used to study the effects of cell shape on local absorption and microthermal effects under electrical stimulation.