Data Recording, Amplification, and Acquisition System for Microelectrode Array

Multi-Electrode Array (MEA) is a Nan technology device used for in-vitro neuron culture and their electrophysiological signal recording. The analysis of these signals is useful to the study of the neuronal network dynamics and the drug tests in pharmacological applications, between others. This paper describes the development of an alternative system of data acquisition to a MEA of 60 microelectrodes, denoted R2AS. The obtained results show that the proposed system is feasible to record the microelectrode signals of some μV level, using a head stage pre-amplifier, filter, amplifier, analog-to-digital converter, with analog multiplexing, and USB converter. The design is scalable and can be used to a high density MEA of 256 channels, replicating the modules, also, the system is flexible, allowing to be adapted to systems as Brain Computer Interface (BCI) with minimal changes.