Ultrasonic propagation simulations in biological tissues with application to the sonodynamic therapy based on ACTRAN

Compared with conventional therapy techniques, sonodynamic therapy of atherosclerosis can achieve non-invasive radical treatment. Currently the treatment parameters are mostly determined empirically. This paper is to describe the establishment of ultrasonic propagation simulation model of atherosclerotic biological tissues by identifying and extracting the medical image feature, together with the study of parameters of the ultrasonic properties of a single type of tissue and the study of the ultrasonic properties of boundary conditions of tissues in simulation model. Based on it, an acoustic simulation software ACTRAN is used to make the simulation analysis for the ultrasonic propagation in biological tissues with the parameters in sonodynamic therapy process. These works can provide the basis for formulating of precise treatment parameters and lay the foundation for the clinical application of sonodynamic therapy for atherosclerosis.