Simple transcriptional networks for differentially expressed genes

Transcriptional regulations in eukaryotes occur through the coordinated regulations of multiple transcription factors (TF). These transcriptional regulations are responsible for changes in expression levels between different environmental conditions or developmental stages of many genes. Some recent microarray studies have focused on the combinational nature of TF interactions. In this work we have developed a novel correlative procedure to find out the pairs of TFs, which can work together, based upon their actions (regulations) on target genes. In this context we have also found the best regulated targeted genes corresponding to a pair of TFs. In the result section we have shown that our approach is capable to find out the significant interaction networks among the TFs and target genes and between the TFs also.