Research on preprocessing of DNase signal in DNAprotein binding sites detection

There are many functional proteins in human cells, which bind in genes and regulate their expression. Accurately identifying binding sites of these proteins is an important and difficult job in life science. To solve this problem, a new DNA protein binding site detection technology, named DNase-Seq emerges. DNase-Seq has great advantages, but its detection signal is quite complex, which makes accurately identifying DNA protein binding site a challenging task. We in-depth analyze DNase-Seq signals and propose a novel preprocessing method. The corresponding experiment proves validity of the method.