Title :
Biosensors based on spectral correlation interferometry for biomedical research and diagnostics
Author :
Nikitin, P.I. ; Orlov, A.V. ; Nikitin, M.P. ; Ksenevich, T.I. ; Gorshkov, B.G.
Author_Institution :
Prokhorov Gen. Phys. Inst., Moscow, Russia
fDate :
June 30 2014-July 4 2014
Abstract :
Biosensors based on the spectral correlation interferometry (SCI) with assistance of magnetic nanoparticles (MP) have been developed for medical diagnostics. The SCI has been adapted for studies of affinity constants of MP covered by antibodies and for detection of protein molecules in human serum. The 50-nm MP employed as labels yield 100-fold amplification of the SCI signals to meet the requirements for myocardial infarction diagnostics.
Keywords :
biomedical equipment; biosensors; interferometry; magnetic particles; molecular biophysics; nanomagnetics; nanomedicine; nanoparticles; patient diagnosis; proteins; MP affinity constants; SCI signal amplification; antibodies; biomedical diagnosis; biomedical research; biosensors; human serum; magnetic nanoparticles; myocardial infarction diagnosis; protein molecule detection; spectral correlation interferometry; Biosensors; Glass; Myocardium; affinity constants; antibody; autoantibodies; biosensors; cardiac troponin I; interferometry; magnetic nanoparticles;
Conference_Titel :
Laser Optics, 2014 International Conference
Conference_Location :
Saint Petersburg
Print_ISBN :
978-1-4799-3884-1
DOI :
10.1109/LO.2014.6886457
