Biosensors based on spectral correlation interferometry for biomedical research and diagnostics

Author

Nikitin, P.I. ; Orlov, A.V. ; Nikitin, M.P. ; Ksenevich, T.I. ; Gorshkov, B.G.

Author_Institution

Prokhorov Gen. Phys. Inst., Moscow, Russia

fYear

2014

fDate

June 30 2014-July 4 2014

Firstpage

1

Lastpage

1

Abstract

Biosensors based on the spectral correlation interferometry (SCI) with assistance of magnetic nanoparticles (MP) have been developed for medical diagnostics. The SCI has been adapted for studies of affinity constants of MP covered by antibodies and for detection of protein molecules in human serum. The 50-nm MP employed as labels yield 100-fold amplification of the SCI signals to meet the requirements for myocardial infarction diagnostics.

Keywords

biomedical equipment; biosensors; interferometry; magnetic particles; molecular biophysics; nanomagnetics; nanomedicine; nanoparticles; patient diagnosis; proteins; MP affinity constants; SCI signal amplification; antibodies; biomedical diagnosis; biomedical research; biosensors; human serum; magnetic nanoparticles; myocardial infarction diagnosis; protein molecule detection; spectral correlation interferometry; Biosensors; Glass; Myocardium; affinity constants; antibody; autoantibodies; biosensors; cardiac troponin I; interferometry; magnetic nanoparticles;

fLanguage

English

Publisher

ieee

Conference_Titel

Laser Optics, 2014 International Conference

Conference_Location

Saint Petersburg

Print_ISBN

978-1-4799-3884-1

Type

conf

DOI

10.1109/LO.2014.6886457

Filename

6886457