Title :
A microfluidic static gradient generator using limited diffusuon through T-shaped narrow channels
Author :
Tamura, Masato ; Maeda, Shigenobu ; Ogawa, Tomomi ; Tanaka, Mitsuru ; Futai, Nobuyuki
Author_Institution :
Sch. of Eng., Shibaura Inst. of Technol., Tokyo, Japan
Abstract :
We have developed a poly (dimethylsiloxane) (PDMS)-cast microfluidic chip that contains a thin (cross-sectional area less than 1.0 μm2) but high aspect ratio (1:1 ~ 1:3) microchannels. Experimental results showed that the gradient of an example of test substances (sodium fluorescein) remained constant in the thin channel over a long period of time (30 minutes) by simple manual liquid handling. We aim to develop a thinner channel keeping the gradient longer time.
Keywords :
bioMEMS; diffusion; lab-on-a-chip; microchannel flow; organic compounds; polymers; PDMS cast microfluidic chip; T-shaped narrow channels; fluid gradient; limited diffusion; manual liquid handling; microfluidic static gradient generator; poly(dimethylsiloxane); sodium fluorescein; thin high aspect ratio microchannels; Fabrication; Generators; Glass; Microchannels; Microfluidics; Resists; Slabs;
Conference_Titel :
Micro-NanoMechatronics and Human Science (MHS), 2014 International Symposium on
Conference_Location :
Nagoya
Print_ISBN :
978-1-4799-6678-3
DOI :
10.1109/MHS.2014.7006121
