DocumentCode
1794875
Title
Microelectronic circuits analogous to hydrogen bonding networks in Michaelis complex of beta-lactamase protein
Author
Gieva, E. ; Rusev, Rostislav ; Angelov, George ; Radonov, R. ; Hristov, Marin
Author_Institution
Dept. of Microelectron., Tech. Univ. of Sofia, Sofia, Bulgaria
fYear
2014
fDate
7-11 May 2014
Firstpage
278
Lastpage
283
Abstract
A microelectronic circuit of block-elements functionally analogous to two hydrogen bonding networks is investigated in the present paper. The hydrogen bonding networks are extracted from Michaelis complex of β-lactamase protein. They are described by electrical circuits. The hydrogen bonds of the networks are presented by three- or four-terminal block-elements in the juxtaposed electrical circuits. The block-elements are coded in Matlab with polynomials and static and dynamic analyses are performed. The circuits´ behavior appeared to be similar to current source or amplifier, and signal modulator.
Keywords
hydrogen bonds; integrated circuit modelling; proteins; β-lactamase protein; Matlab; Michaelis complex; amplifier; beta-lactamase protein; circuit behavior; current source; electrical circuits; four-terminal block-elements; hydrogen bonding networks; microelectronic circuits; polynomials; signal modulator; three-terminal block-elements; Bonding; Equations; Hydrogen; Mathematical model; Microelectronics; Proteins; Springs;
fLanguage
English
Publisher
ieee
Conference_Titel
Electronics Technology (ISSE), Proceedings of the 2014 37th International Spring Seminar on
Conference_Location
Dresden
Type
conf
DOI
10.1109/ISSE.2014.6887608
Filename
6887608
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