• DocumentCode
    1794875
  • Title

    Microelectronic circuits analogous to hydrogen bonding networks in Michaelis complex of beta-lactamase protein

  • Author

    Gieva, E. ; Rusev, Rostislav ; Angelov, George ; Radonov, R. ; Hristov, Marin

  • Author_Institution
    Dept. of Microelectron., Tech. Univ. of Sofia, Sofia, Bulgaria
  • fYear
    2014
  • fDate
    7-11 May 2014
  • Firstpage
    278
  • Lastpage
    283
  • Abstract
    A microelectronic circuit of block-elements functionally analogous to two hydrogen bonding networks is investigated in the present paper. The hydrogen bonding networks are extracted from Michaelis complex of β-lactamase protein. They are described by electrical circuits. The hydrogen bonds of the networks are presented by three- or four-terminal block-elements in the juxtaposed electrical circuits. The block-elements are coded in Matlab with polynomials and static and dynamic analyses are performed. The circuits´ behavior appeared to be similar to current source or amplifier, and signal modulator.
  • Keywords
    hydrogen bonds; integrated circuit modelling; proteins; β-lactamase protein; Matlab; Michaelis complex; amplifier; beta-lactamase protein; circuit behavior; current source; electrical circuits; four-terminal block-elements; hydrogen bonding networks; microelectronic circuits; polynomials; signal modulator; three-terminal block-elements; Bonding; Equations; Hydrogen; Mathematical model; Microelectronics; Proteins; Springs;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Electronics Technology (ISSE), Proceedings of the 2014 37th International Spring Seminar on
  • Conference_Location
    Dresden
  • Type

    conf

  • DOI
    10.1109/ISSE.2014.6887608
  • Filename
    6887608