Title :
Memristive trans-impedance amplifier (mTIA) and its application to DNA sequencing
Author :
Sangho Shin ; Le Zheng ; Kyungmin Kim ; Sung-Mo Kang
Author_Institution :
Dept. of EE, Univ. of California, Santa Cruz, Santa Cruz, CA, USA
Abstract :
This paper investigates a new analog memristor application to nanopore-based DNA sequencing systems, where the memristors´ property of dynamic resistance is utilized to effectively amplify the DNA translocation induced block-to-open ratio of the pore resistance to sense. For a demonstrative case with memristors´ off-to-on resistance ratio of 100 and nanopore´s block-to-open channel resistance ratio of 10, this paper shows that the utilization of a memristor as the feedback resistor of a transimpedance amplifier can boost the sensing window by additional ratio of 10.
Keywords :
DNA; biological techniques; memristors; operational amplifiers; DNA translocation-induced block-to-open ratio; analog memristor application; dynamic resistance; feedback resistor; mTIA; memristive transimpedance amplifier; memristor off-to-on resistance ratio; nanopore block-to-open channel resistance ratio; nanopore-based DNA sequencing systems; pore resistance; sensing window; DNA; Immune system; Memristors; Nanobioscience; Resistance; Sensors; Sequential analysis;
Conference_Titel :
Cellular Nanoscale Networks and their Applications (CNNA), 2014 14th International Workshop on
Conference_Location :
Notre Dame, IN
DOI :
10.1109/CNNA.2014.6888593
