Parameter sensitivity analysis for the Calvin cycle by use of an algebraic-equation method

This paper takes a simplified model for example to investigate the parameter sensitivity of the Calvin cycle. A parameter sensitivity analysis method is proposed by Taylor expansion and multi-linear regression. The rationality of the method is discussed and the definition of sensitivity vector is introduced to describe the role of each parameter and an algorithm is proposed to study parameter sensitivity of a class of biochemical reactions described by differential equations. Using such method, the sensitivity vector of the steady-state concentration of each metabolite in the Calvin cycle is obtained and the one of overall variables containing the interaction of parameters is also derived.